Levels of α 1 -Antitrypsin in Plasma and Risk of Spontaneous Cervical Artery Dissections
- 1 September 2003
- journal article
- research article
- Published by Wolters Kluwer Health in Stroke
- Vol. 34 (9) , E168-9
- https://doi.org/10.1161/01.str.0000085085.20390.a3
Abstract
Background and Purpose— Abnormalities of dermal connective tissue have been detected in patients with spontaneous cervical artery dissections (sCAD), suggesting an underlying structural defect of the arterial wall. α 1 -Antitrypsin (A1-AT) is a circulating serine proteinase inhibitor of proteolytic enzymes that helps to maintain the integrity of elastic and collagen fibers. Methods— To test the hypothesis that moderate deficiency of A1-AT may be a risk factor for sCAD, 22 cases with sCAD and 113 controls were included in the study. Results— Patients with sCAD had significantly mean lower levels of A1-AT compared with controls (116.0±24.9 versus 141.1±31.7 mg/dL; P P r =0.22; P Conclusions— Low plasma levels of A1-AT may be a risk factor for sCAD.Keywords
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