Immune Inhibition of Virus Release from Herpes Simplex Virus-Infected Cells by Human Sera
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in Intervirology
- Vol. 29 (3) , 125-132
- https://doi.org/10.1159/000150038
Abstract
Human sera contain antibody (IVR antibody) which will inhibit the release of herpes simplex virus type 1 from virus-infected cells. This antibody activity was removed by adsorption of sera with virus-infected cell extract. There was a positive correlation between IVR and neutralizing antibody activity, particularly when measured by augmented neutralization test; measurement of IVR antibody was equally as sensitive as measurement of neutralizing antibody by augmented neutralization test. IVR antibody levels provided indication of a history of recurrent herpes labialis, the pattern of antibody response following primary herpetic infection, and indication of response to Skinner herpes vaccine in human subjects. It is suggested that consideration should be given to measurement of IVR antibody in both clinical and epidemiological studies of herpes and other virus infections.Keywords
This publication has 2 references indexed in Scilit:
- Augmentation of the neutralisation test for type 1 HSV: Evidence of high representation of neutralising antibody in the adult communityMedical Microbiology and Immunology, 1985
- The relative infrequency and low levels of neutralising and immunoprecipitating antibody to herpes simplex viruses types 1 and 2 in patients with a history of recurrent herpes genitalisMedical Microbiology and Immunology, 1983