Simulating genetic networks made easy: network construction with simple building blocks
Open Access
- 19 August 2004
- journal article
- research article
- Published by Oxford University Press (OUP) in Bioinformatics
- Vol. 21 (2) , 269-271
- https://doi.org/10.1093/bioinformatics/bth478
Abstract
Summary: We present SIM-plex, a genetic network simulator with a very intuitive interface in which a user can easily specify interactions as simple ‘if-then’ statements. The simulator is based on the mathematical model of Piecewise Linear Differential Equations (PLDEs). With PLDEs, genetic interactions are approximated as acting in a switch-like manner. Availability: The Java program, examples and a tutorial are available at http://www.psb.ugent.be/cbd/ Contact:{stcru,makui}@psb.ugent.beKeywords
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