Serum lactate dehydrogenase isoenzyme pattern in neuroblastoma
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in European Journal of Nuclear Medicine and Molecular Imaging
- Vol. 123 (2) , 83-87
- https://doi.org/10.1007/bf00442638
Abstract
Total serum LDH activity and isoenzyme distribution were studied in children with neuroblastoma at the time of hospital admission. The total LDH was determined in 26 cases, and 20 (77%) of them showed elevation of its activity. On the other hand, in 9 of these 26 cases, the isoenzyme distribution was determined along with the total LDH. All 9 cases, 4 of them with normal total LDH activity, showed an abnormal isoenzyme pattern with a percentage increase in the intermediate fractions (malignant pattern). The results suggest the usefulness of the determination of serum LDH isoenzymes as a screening procedure in children with malignant tumors including neuroblastoma.Keywords
This publication has 16 references indexed in Scilit:
- Serum Lactate Dehydrogenase Isoenzyme and Total Lactate Dehydrogenase Values in Health and Disease, and Clinical Evaluation of These Tests by Means of Discriminant AnalysisAmerican Journal of Clinical Pathology, 1969
- Total LDH and LDH isoenzyme distribution in the serum of normal childrenClinica Chimica Acta; International Journal of Clinical Chemistry, 1968
- CLINICAL APPLICATIONS OF LACTATE DEHYDROGENASE ISOZYMES: ALTERATIONS IN MALIGNANCYAnnals of the New York Academy of Sciences, 1968
- Clinical Application and Interpretation of the Serum Lactic Dehydrogenase ZymogramAmerican Journal of Clinical Pathology, 1966
- A rapid colorimetric assay for serum lactic dehyurogenaseClinica Chimica Acta; International Journal of Clinical Chemistry, 1965
- Serum Lactic Dehydrogenase and Ribonuclease in the Diagnosis of Malignant Tumours in ChildrenArchives of Disease in Childhood, 1965
- Lactate dehydrogenase isoenzymes: Irregularities in electrophoretic mobilityClinica Chimica Acta; International Journal of Clinical Chemistry, 1965
- Serum Lactic Dehydrogenase Activity and Isoenzyme Patterns in Some Haematological DiseasesActa Medica Scandinavica, 1965
- A simplified method of demonstrating lactic dehydrogenase isoenzymes in serumClinica Chimica Acta; International Journal of Clinical Chemistry, 1962
- Localization of Lactic Acid Dehydrogenase Activity in Serum FractionsExperimental Biology and Medicine, 1957