Dumbbell-like Au−Fe3O4 Nanoparticles for Target-Specific Platin Delivery
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- 10 March 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 131 (12) , 4216-4217
- https://doi.org/10.1021/ja900790v
Abstract
Dumbbell-like Au−Fe3O4 nanoparticles (NPs) were made and coupled with Herceptin and a platin complex. The platin−Au−Fe3O4−Herceptin NPs act as a target-specific nanocarriers for delivery of platin into Her2-positive breast cancer cells (Sk-Br3) with strong therapeutic effects. The conjugate has a half-maximal inhibitory concentration (IC50) toward Sk-Br3 cells of 1.76 μg of Pt/mL, which is lower than that needed for cisplatin (3.5 μg/mL). The work demonstrates that the dumbbell-like Au−Fe3O4 NPs are promising nanocarriers for highly sensitive diagnostic and therapeutic applications.This publication has 12 references indexed in Scilit:
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