Antibody-mediated Infection of P388D1 Cells with 17D Yellow Fever Virus: Effects of Chloroquine and Cytochalasin B
- 1 April 1984
- journal article
- Published by Microbiology Society in Journal of General Virology
- Vol. 65 (4) , 791-794
- https://doi.org/10.1099/0022-1317-65-4-791
Abstract
Antibody-mediated 17D yellow fever virus infection of a murine macrophage-like cell line, P388D1, was not inhibited by concentrations of cytochalasin B which did inhibit phagocytosis of antibody-coated sheep red blood cells. Chloroquine did not affect antibody-mediated enhancement of viral growth but inhibited viral replication equally whether infection was carried out in the presence or absence of antibody. The results suggest that the route of internalization of virus and subsequent intracellular pathways of replication are similar for both conditions of infection.Keywords
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