Telomere Diseases
Top Cited Papers
- 10 December 2009
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 361 (24) , 2353-2365
- https://doi.org/10.1056/nejmra0903373
Abstract
The Nobel Prize in Physiology or Medicine 2009 was recently awarded to three scientists for their work on telomeres, which are repetitive DNA structures at the tips of chromosomes, and the enzyme telomerase. Telomeres protect the genome from loss of genetic material. This review recounts the medical implications of telomeres and focuses on a group of diseases in which the loss of telomeres appears to be causal.Keywords
This publication has 102 references indexed in Scilit:
- Genetic variation in telomere maintenance genes, telomere length, and lung cancer susceptibilityLung Cancer, 2009
- Genome‐wide profiling of chromosomal alterations in renal cell carcinoma using high‐density single nucleotide polymorphism arraysInternational Journal of Cancer, 2009
- New common variants affecting susceptibility to basal cell carcinomaNature Genetics, 2009
- Dyskeratosis congenita: The first NIH clinical research workshopPediatric Blood & Cancer, 2009
- Targeting the telosome: Therapeutic implicationsBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2009
- Lung cancer susceptibility locus at 5p15.33Nature Genetics, 2008
- Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenitaProceedings of the National Academy of Sciences, 2008
- TINF2, a Component of the Shelterin Telomere Protection Complex, Is Mutated in Dyskeratosis CongenitaPublished by Elsevier ,2008
- Genetic variation in five genes important in telomere biology and risk for breast cancerBritish Journal of Cancer, 2007
- Conditional telomerase induction causes proliferation of hair follicle stem cellsNature, 2005