The Effect of a Progesterone‐Induced Immunologic Blocking Factor on NK‐Mediated Resorption
- 1 December 1990
- journal article
- Published by Wiley in American Journal of Reproductive Immunology
- Vol. 24 (4) , 105-107
- https://doi.org/10.1111/j.1600-0897.1990.tb01047.x
Abstract
Transfer of spleen cells from poly (I)-poly(C12U)-treated Balb/c mice to 6.5-days-pregnant Balb/c mice significantly increased the resorption rate (P less than 0.01) from 11% to 48%. The supernatant of progesterone-treated spleen cells from pregnant C3H mice abrogated the effect of spleen cell transfer. We conclude that by blocking NK activity in vivo, the progesterone-induced blocking factor favors the maintenance of pregnancy.Keywords
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