Ascorbic Acid and Its Effect on the Skin of Bufo regularis

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Abstract
Skin papillomas were observed in the majority of toads when painted with 1 mg of 7,12-dimethyl-benz(α)anthracene (DMBA) daily for 8 weeks. Animals injected with 10 mg/kg/day of ascorbic acid into the dorsal lymph sac showed tumor inhibition when painted with the same dose level of DMBA for 8 weeks. Tumor regression occurred in those animals receiving 10 mg/kg/day of ascorbic acid for 8 weeks.