Age‐dependent cognitive decline in the APP23 model precedes amyloid deposition
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- 10 January 2003
- journal article
- research article
- Published by Wiley in European Journal of Neuroscience
- Vol. 17 (2) , 388-396
- https://doi.org/10.1046/j.1460-9568.2003.02444.x
Abstract
Heterozygous APP23 mice, expressing human amyloid‐precursor protein with the Swedish double mutation and control littermates, were subjected to behavioral and neuromotor tasks at the age of 6–8 weeks...Keywords
This publication has 37 references indexed in Scilit:
- The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to TherapeuticsScience, 2002
- Applications of the Morris water maze in the study of learning and memoryPublished by Elsevier ,2001
- Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695Journal of Biological Chemistry, 2001
- Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's diseaseNature, 2000
- Behavioral disturbances in transgenic mice overexpressing the V717F Β-amyloid precursor protein.Behavioral Neuroscience, 1999
- Neurofibrillary degeneration and cell loss in the nucleus basalis in comparison to cortical Alzheimer pathologyNeurobiology of Aging, 1998
- AßT Amyloidogenesis: Unique, or Variation on a Systemic ThemeCritical Reviews in Biochemistry and Molecular Biology, 1997
- Spatial learning deficit in mice expressing human 751-amino acid β-amyloid precursor proteinNeuroReport, 1996
- Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteinsNeuron, 1995
- Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's diseaseNeurology, 1992