Since multiple sclerosis was first described in 1835, an unending search has been conducted for therapeutic weapons with which to combat the disease. An incomplete and casual list of some of the agents recommended and used for this purpose includes potassium iodide, sodium cacodylate, and arsenic in many forms. Colloidal preparations of gold, selenium, manganese, and antimony have apparently proved of value. Sodium salicylate has been given intravenously. Mercury, phosphorus, lecithin, nucleoproteins, lymphoid serums, and fibrolysins have been advocated. Artificial fevers produced by radiant heat, malaria, milk, and the vaccines of typhoid, paratyphoid and Streptococcus organisms have been suggested. The disease has been treated with glandular extracts, whole liver, numerous vitamins, penicillin, the sulfonamides, histamine, the antihistamines, goats' milk, bishydroxycoumarin (dicumarol®), neostigmine, and psychoanalysis. All of these remedies are claimed to have cured some patients of their disease. All of them have seemed capable of altering the course of a