Inhibition of cell proliferation of human gliomas by benzodiazepinesin vitro
- 1 March 1988
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 77 (3) , 231-233
- https://doi.org/10.1111/j.1600-0404.1988.tb05900.x
Abstract
— The effects of several benzodiazepines (diazepam, clonazepam, Ro 15–1788 and Ro 5–4864) on cell proliferation of 2 human gliomas were estimated in vitro by means of [3H]-thymidine uptake assay. It was found that all tested benzodiazepines suppressed [3H]-thymidine incorporation into the DNA of glioma cells, the effects being stronger in case of peripheral-type benzodiazepine receptor ligands. The results indicated that benzodiazepines might exert an antiproliferative action on glioma tumour cells growth.Keywords
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