Amiloride-sensitive sodium channels and expression of sodium appetite in rats
- 1 August 1987
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Vol. 253 (2) , R371-R374
- https://doi.org/10.1152/ajpregu.1987.253.2.r371
Abstract
Lingual application of amiloride hydrochloride blocks a sodium transport system in the mammalian gustatory system. Effects of exposure to amiloride on subsequent licking for 3% NaCl by rats were found to differ as a function of the animal's sodium balance. Licking for 3% NaCl was significantly increased in sodium-replete rats and significantly decreased in sodium-deplete rats by amiloride pretreatment. In fact, expression of sodium appetite was virtually eliminated by pretreatment with amiloride. This suggests that the recognition of sodium solutions in animals with a sodium deficit is dependent on amiloride-sensitive sodium transport at the taste bud.This publication has 4 references indexed in Scilit:
- Attenuated sodium appetite in response to sodium deficiency in Fischer-344 ratsAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1987
- Analysis of amiloride inhibition of chorda tympani taste response of rat to NaClAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1985
- Salt Taste Transduction Occurs Through an Amiloride-Sensitive Sodium Transport PathwayScience, 1984
- Amiloride reduces the taste intensity of Na+ and Li+ salts and sweeteners.Proceedings of the National Academy of Sciences, 1983