Induction of Specific Unresponsiveness Against the C3H Mls-Antigen in Mice. Increase of Suppressive Capacity of C3H × CBA F1-Lymphocytes after Sensitization Against CBA Lymphoid Cells
- 1 January 1978
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 56 (3) , 238-246
- https://doi.org/10.1159/000232027
Abstract
Injection of adult CBA mice with lymphocytes from C3H × CBA donors leads to a specific reduction of the MLC reactivity of the recipients’ lymphocytes. This effect is mediated by a population of Fl-lymphocytes which do not seem to possess the relevant MLC-stimulatory Mls-antigen. In this investigation we have shown that injection of C3H × CBA mice with CBA, but not C3H spleen cells enhances the ‘tolerogenic’ capacity of their thymocytes and lymph node cells. A similar enhancing effect was achieved by ‘educating’ C3H × CBA lymphocytes in irradiated CBA, but not C3H hosts. The results indicate that C3H × CBA lymphocytes reduce the MLC-reactivity by reacting immunologically against CBA T-cells which possess recognition structures for the relevant Mis antigen. Lymphocytes of C3H × CBA mice can be sensitized against such recognition structures which thus renders them more ‘tolerogenic’.Keywords
This publication has 1 reference indexed in Scilit:
- Capacity of C3H × CBA spleen cells to depress the MLC response of CBA mice specificallyCellular Immunology, 1976