Cytohistologic Evaluation of the Liver: Imprint and Smear Cytology and Intraoperative Frozen Section

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Abstract
The preoperative diagnosis of hepatic masses has a direct impact on patient management and therapy. A combined cytohistologic approach provides improved diagnostic sensitivity and specificity. Cytologic evaluation in the intraoperative setting is also an important adjunctive diagnostic tool to conventional frozen section. Preoperative or intraoperative cytologic evaluation, in addition to conventional frozen section, should be considered an integral part of the diagnostic armamentarium in the diagnosis of hepatic mass lesions. A case is presented that illustrates this combined approach.