1-(Naphthylalkyl)-1H-imidazole derivatives, a new class of anticonvulsant agents

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Abstract
Potent anticonvulsant activity was demonstrated for a large number of 1-(naphthylalkyl)-1H-imidazoles containing a variety of functional groups in the alkylene bridge. The presence of a small O2 function in the bridge, in general, confers a high therapeutic index between anticonvulsant and depressant activity. Clinical expectations are discussed for 1-(2-naphthoylmethyl)imidazole hydrochloride, which is undergoing development for testing in humans.

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