Increased Secretion of Müllerian Inhibiting Substance after Immunological Blockade of Endogenous Luteinizing Hormone Releasing Hormone in the Rat
- 1 February 1978
- journal article
- research article
- Published by Springer Nature in Pediatric Research
- Vol. 12 (2) , 139-142
- https://doi.org/10.1203/00006450-197802000-00015
Abstract
Summary: In order to evaluate the role of leuteinizing hormone releasing hormone (LHRH) and gonadotropins in the control of secretion of Müllerian inhibiting substance, groups of pregnant rats were injected intraperitoneally with high potency antiserum from a rabbit immunized with LHRH. Pregnant females were injected at 13 and 20 days of gestation with LHRH antiserum or an equal volume of normal rabbit serum as a control. The testes and penis were reduced in weight and size in 6-day-old pups of the experimental group indicating the luteinizing hormone (LH) was blocked and that LHRH antiserum was active. Testicular fragments of 17-day fetuses and 6-day-old pups showed an increase relative to controls in Müllerian inhibiting substance activity in a graded organ culture bioassay system. These studies suggest that secretion of Müllerian inhibiting substance is curtailed by one or both gonadotropins. Speculation: The secretion of Müllerian inhibiting substance is under inhibitory gonadotropin control, dependent on normal hypothalamic secretion of LHRH.Keywords
This publication has 2 references indexed in Scilit:
- The Production of Mullerian Inhibiting Substance by the Fetal, Neonatal and Adult Rat1Biology of Reproduction, 1976
- Effect of Active and Passive Immunization with Luteinizing Hormone-Releasing Hormone on Serum LuteinizingHormone and Follicle-Stimulating Hormone Levels nd the Ultrastructure of the Pituitary Gonadotrophs in Castrated Male RatsEndocrinology, 1976