USE OF SODIUM DIPHENYL HYDANTOINATE AS ANTICONVULSANT

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To the Editor:— It is gratifying to see Dr. Kimball's report testifying to the effectiveness of sodium diphenyl hydantoinate as an anticonvulsant as used in his series of 152 cases since the beginning of 1938 (The Treatment of Epilepsy with Sodium Diphenyl Hydantoinate,The Journal, April 1, p. 1244). His was the first clinic to which the drug was furnished after Dr. Merritt and I had given it a ten months trial under rigid precautions in our own wards. This in turn was only after we had demonstrated its ability to prevent experimentally produced convulsions and its low toxicity in animals (Putnam, T. J., and Merritt, H. H.: Experimental Determination of the Anticonvulsant Properties of Some Phenyl Derivatives,Science85:525 [May 28] 1937). His observations are therefore of particular value. It is of course of great importance to record, as Dr. Kimball has done, any peculiar side effects which

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