The synthesis of .EPSILON.-rhodomycinone- and carminomycin-11-methyl ethers.
- 1 January 1979
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 32 (3) , 247-249
- https://doi.org/10.7164/antibiotics.32.247
Abstract
The conversion of epsilon-rhodomycinone to its 11-methyl ether via selective hydrolysis of the 4,6,7,11-tetraacetate is described. This series of reactions was used as a model for the conversion of carminomycin to its 11-methyl ether. The anti-tumor activity of the latter compound was less than that of both carminomycin and its 4-methyl ether (daunomycin).Keywords
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