EXPRESSION OF INSULIN-LIKE GROWTH FACTOR-II MESSENGER-RNA IN FETAL KIDNEY AND WILMS TUMOR - AN INSITU HYBRIDIZATION STUDY

  • 1 November 1989
    • journal article
    • research article
    • Vol. 61  (5) , 522-526
Abstract
The pattern of insulin-like growth factor II (IGF-II) mRNA expression in developing kindey and Wilm''s tumor was examined with in situ hybridization. In developing kidney, IGF-II was primarily expressed in blastemal cells and lost with their differentiation. In triphasic Wilms'' tumor, a similar relationship was found. But in a monomorphous Wilms'', tumor cells with epithelial differentiation expressed IGF-II mRNA. These data suggest that IGF-II may be involved in fetal nephrogenesis, that its expression is inversely coupled to normal epithelial differentiation, and that this differentiation may be aberrantly regulated in Wilm''s tumor.