Visual attention in long-term survivors of leukemia receiving cranial radiation therapy
- 1 March 2004
- journal article
- research article
- Published by Cambridge University Press (CUP) in Journal of the International Neuropsychological Society
- Vol. 10 (2) , 211-220
- https://doi.org/10.1017/s1355617704102075
Abstract
The effect of cranial radiation therapy (CRT) on visual attention was examined in long-term survivors of childhood acute lymphoblastic leukemia (ALL) compared to peers with no history of ALL (n= 24) using a cued orienting task and a global–local task. ALL participants treated with CRT (n= 13) demonstrated an increased cost in response time with invalid spatial orienting cues and inefficient shifts of attention across hierarchical levels. ALL participants treated only with chemotherapy (n= 8) showed performance similar to the non-ALL comparison group. Participants with exposure to CRT early in life appeared to largely account for the attention deficits, and showed particular difficulties with shifting attention from the local level of stimuli to the global level. The data are consistent with prior reports emphasizing attention deficits following CRT, and suggest that attention shifting may be particularly affected by CRT early in life. (JINS, 2004,10, 211–220.)Keywords
This publication has 48 references indexed in Scilit:
- Processing speed, working memory, and IQ: A developmental model of cognitive deficits following cranial radiation therapy.Neuropsychology, 2000
- Effects of Background Color on the Global and Local Processing of Hierarchically Organized StimuliJournal of Cognitive Neuroscience, 1999
- Quantitative EEG in long-term survivors of acute lymphoblastic leukemiaPediatric Neurology, 1996
- The effects of bifrontal stroke during childhood on visual attention: Evidence from children with sickle cell anemiaDevelopmental Neuropsychology, 1994
- Intellectual function in long-term survivors of childhood acute lymphoblastic leukemia: Protective effect of pre-irradiation methotrexate a childrens cancer study group studyMedical and Pediatric Oncology, 1991
- Neurotoxicity in lymphoblastic leukaemia: comparison of oral and intramuscular methotrexate and two doses of radiation.Archives of Disease in Childhood, 1990
- Memory and Learning Sequelae in Long-term Survivors of Acute Lymphoblastic LeukemiaJournal of Pediatric Hematology/Oncology, 1990
- Neurobehavioral effects of central nervous system prophylactic treatment of cancer in childrenJournal of Clinical and Experimental Neuropsychology, 1988
- Neuropsychological Effects of Childhood Cancer TreatmentJournal of Child Neurology, 1988
- Hemispheric specialization of memory for visual hierarchical stimuliNeuropsychologia, 1986