FURTHER OBSERVATIONS ON THE EMPLOYMENT OF SPECIFIC AND NON-SPECIFIC ANTIGENS IN THE PERFORMANCE OF THE GONOCOCCIC COMPLEMENT-FIXATION TEST
- 1 February 1915
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. XV (2) , 265-268
- https://doi.org/10.1001/archinte.1915.00070200087006
Abstract
In a former paper1 read before the Philadelphia County Medical Society May 28, 1913, it was conclusively shown by Thomas and Ivy in an analysis of over 200 cases in which monavalent, trivalent, hexavalent and a commercial antigen of twelve strains of gonococci were employed, that the gonococcus complement-fixation test possesses great specificity so far as positive results are concerned. The results have proved that "the different strains of the gonococcus differ markedly one from another — so much so that the antibodies produced in the body by the toxin of one strain will in many instances not bind the complement in the presence of an antigen prepared from another strain. Therefore, if only one strain is used in the preparation of the antigen, a great many negative results would be obtained in positive cases ; an antigen prepared from many strains fixes the complement whenever one of itsThis publication has 0 references indexed in Scilit: