Curative resection of gastric cancer: Limitation of peritoneal lavage cytology in predicting the outcome

Publisher Website
Google Scholar
Abstract
Patients with stage T3N0∼2M0 gastric carcinoma (n = 108) were studied for relevant prognostic factors. Peritoneal lavage cytology (PLC) was performed in all. In univariate analysis, 5‐year survival rates were better with smaller serosal invasion (diameter P< 0.05) and fewer metastatic nodes (≤5 vs. ≥6, 57% vs. 29%,P< 0.05). In multivariate analyses, only these two factors were significant. The predictive value of PLC was not shown in both univariate and multivariate analyses. Peritoneal recurrence occured in 14 (22%) of 77 patients with negative PLC, and in 3 (18%) of 17 with positive PLC, the difference being not significant. Our results indicate that PLC is insensitive in predicting the development of peritoneal recurrence. Its role in the estimation of survival is limited, as many will die of visceral or locoregional recurrence if not of peritoneal dissemination.