EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF 6-HYDROXYDOPAMINE AND 5,6-DIHYDROXYTRYPTAMINE ON THE PHASIC SECRETION OF LUTEINIZING-HORMONE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 35  (2) , 163-168
Abstract
In ovariectomized rats carrying an estradiol sylastic implant the effect of the intraventricular administration of the serotonin neurotoxin 5,6-dihydroxytryptamine and of the norepinephrine neurotoxin 6-hydroxydopamine on the circadian secretion of the luteinizing hormone (LH) was studied. The decrease of 5-HT after injection of 5,6-dihydroxytryptamine reduced the a.m. and p.m. values and suppressed the phasic rhythm of LH. The diminution of norepinephrine after administration of 6-hydroxydopamine increased the a.m. and did not alter the p.m. values, resulting in a partial abolition of the rhythm.

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