STUDY OF SULPHAMETHOXAZOLE IN RHEUMATOID ARTHRITIS

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Abstract
Twenty-three patients with rheumatoid arthritis (RA) entered a single-blind cross-over study of sul-phamethoxazole 2 g daily compared to placebo. Sulphamethoxazole was administered for 3 months during the 6-month study. Sulphamethoxazole exhibited properties commensurate with a second-line effect with a significant acute-phase reactant response and a parallel change in the clinical state. Adverse effects were common and resulted in nine drug-related withdrawals, mainly due to nausea and vomiting. There were also reversible abnormalities in liver function tests on the active drug. The role of sulphonamides in treatment of RA requires further exploration.