The syndrome of brittle bones and blue sclerotics is one of those comparatively rare yet interesting hereditary clinical entities which stir the imagination and excite the curiosity of clinician and investigator alike. It is our purpose here to report a case, including a family history of five generations, and to review briefly some of the recent literature bearing on the subject. Key1 in 1926 and Bell2 in 1928 presented comprehensive monographs on this subject. The former furnished the first complete pathologic study, while the latter investigated particularly the hereditary phase and through an exhaustive study of all reported cases presented the most accurate known statistics as to the incidence. A review of their work should constitute a starting point for any discussion of this subject. To this summary will be added other recent contributions. HISTORY According to Bell,2 fragility of the bones due to cancer, tuberculosis and