Digital computer processing of brain scans using principal components

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Abstract
Most of the scan processing methods used to date are unable to distinguish between normal and abnormal features [in man]. A method was described of constructing a particular orthogonal transform from a set of normal images, the method of principal components, which may be used selectively to filter out normal features, leaving behind abnormal features. The method was applied to brain scans and was implemented on a small digital computer system with magnetic disc.