Plasma loss in dogs in irreversible hemorrhagic shock

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Abstract
Dogs were bled into a reservoir which maintained arterial pressure at 35 mm Hg. Control animals were reinfused after 5 min. In shock animals, hemorrhage was maintained until 30% of a maximum bleeding volume returned to the animals; reinfusion was then completed. Plasma volumes were measured before hemorrhage and after reinfusion bv dilution of radioiodine-labeledalbumin. Shock animals underwent a net plasma loss of 18%. Control animals underwent no net loss. Hematocrits in splenectomizedanimals indicatedthat all animals reabsorbed extra-vascular fluid after the initial hemorrhage. The shock animals lost plasma water during the later stages of hemorrhage. All animals lost plasma water during reinfusion. In control animals, plasma volume returned to control levels. A net deficit occurredin shock animals. Shock animals usually lost a moderate amount of plasma water during the postre infusion period. The total plasmaloss in shock animals appeared not to be large enough to be the sole cause of the hemodynamic deterioration observed after reinfusion.

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