A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions
Top Cited Papers
- 15 April 2002
- journal article
- Published by Springer Nature in The EMBO Journal
- Vol. 21 (8) , 1948-1956
- https://doi.org/10.1093/emboj/21.8.1948
Abstract
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.Keywords
This publication has 45 references indexed in Scilit:
- Distinct Intramembrane Cleavage of the β-Amyloid Precursor Protein Family Resembling γ-Secretase-like Cleavage of NotchJournal of Biological Chemistry, 2001
- A Portrait of Alzheimer Secretases--New Features and Familiar FacesScience, 2001
- Cleavage and Shedding of E-cadherin after Induction of ApoptosisJournal of Biological Chemistry, 2001
- L-685,458, an Aspartyl Protease Transition State Mimic, Is a Potent Inhibitor of Amyloid β-Protein Precursor γ-Secretase ActivityBiochemistry, 2000
- Posttranslational Modification and Plasma Membrane Localization of the Drosophila melanogaster PresenilinMolecular and Cellular Neuroscience, 2000
- Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of β-catenin from cell – cell contactsOncogene, 1999
- Matrix Metalloproteinase Stromelysin-1 Triggers a Cascade of Molecular Alterations That Leads to Stable Epithelial-to-Mesenchymal Conversion and a Premalignant Phenotype in Mammary Epithelial CellsThe Journal of cell biology, 1997
- Phosphorylation, Subcellular Localization, and Membrane Orientation of the Alzheimer's Disease-associated PresenilinsJournal of Biological Chemistry, 1997
- Uncoupling cadherin-based adhesion from wingless signalling in DrosophilaNature, 1996
- Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells.The Journal of cell biology, 1994