EFFECT OF TESTOSTERONE PROPIONATE ON THE BODY WEIGHT AND SKELETAL SYSTEM OF HYPOPHYSECTOMIZED RATS SYNERGISM WITH PITUITARY GROWTH HORMONE1

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Abstract
Hypophysec-tomized o and o rats were injtd. for 4 to 20 days with testosterone propionate in daily doses of 0.05-4.0 mg. at 0-100 days post-hypophysectomy. The oo had been operated at 26 days, the males at 30, 40, 60 and 70 days of age. Injs. of testosterone propionate did not cause a significant increase in body wt. or skeletal dimensions in hypophysectomized o or o rats. In oo hypophysectomized at 40 days of age and injected with TP for 15 days following operation, osteogenesis continued somewhat while it stopped in uninjected controls. Also a 10-day period of TP injs. caused some reactivation of the epiphyseal cartilages and osteogenic activity in the tibias of oo which had shown regression 42 to 90 days after hypophysectomy. Simultaneous injs. of TP with growth hormone caused a greater increase in body wt. and skeletal dimensions of hypophysectomized oo than did growth hormone alone, but not significantly so in tests on oo. Neither in hypophysectomized oo or oo was the osteogenesis typically induced by the growth hormone modified by concurrent injs. of TP.

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