Semiconductor microcavity laser spectroscopy of intracellular protein in human cancer cells

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Abstract
The speed of light through a biofluid or biological cell is inversely related to the biomolecular concentration of proteins and other complex molecules comprising carbon- oxygen double bonds that modify the refractive index at wavelengths accessible to semiconductor lasers. By placing a fluid or cell into a semiconductor microcavity laser, these decreases in light speed can be sensitively recorded in picoseconds as frequency red-shifts in the laser output spectrum. This biocavity laser equipped with microfluidics for transporting cells at high speed through the laser microcavity has shown potential for rapid analysis of biomolecular mass of normal and malignant human cells in their physiologic condition without time-consuming fixing, staining, or tagging.

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