Faculty Opinions recommendation of Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism.

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Abstract
This brain imaging study is one of several suggesting that primary major depressive disorder is characterized by abnormal metabolism in the prefrontal cortex limbic structures relevant to mood regulation. A persistent improvement in response to chronic antidepressant drug treatment was correlated with reduced metabolism in the amygdala and ventral anterior cingulate cortex. A possible mechanism for this is through the modulation of mono-aminergic transmission (see also {1}). This Recommendation is of an article referenced in an F1000 Faculty Review also written by Bettina Bewernick and Thomas E Schlaepfer.

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