A Physiologically Based Pharmacokinetic Analysis of Capecitabine, a Triple Prodrug of 5-FU, in Humans: The Mechanism for Tumor-Selective Accumulation of 5-FU
- 1 January 2001
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 18 (8) , 1190-1202
- https://doi.org/10.1023/a:1010939329562
Abstract
Purpose. To identify the factors governing the dose-limiting toxicity in the gastrointestine (GI) and the antitumor activity after oral administration of capecitabine, a triple prodrug of 5-FU, in...Keywords
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