Abstract
There is considerable evidence that activity in central dopaminergic pathways can affect an animal’s responsiveness to noxious stimulation. For example, we have recently found that both the intravenous and intrathecal administration of the dopamine agonist apomorphine (APO) leads to an increase in the tail flick latency (t.f.l.) in the rat (Barasi & Duggal 1984). In the first part of the study we have further investigated the dopamine receptors involved in the mediation of this effect.

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