Snake Neurotoxins: Effect of Disulfide Reduction on Interaction with Electroplax
- 17 December 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 174 (4015) , 1236-1237
- https://doi.org/10.1126/science.174.4015.1236
Abstract
Reduction of disulfide bonds of cobra neurotoxin by dithiothreitol results in decreased activity on the electroplax preparation. Activity is restored completely after reoxidation by 3,3'-dithiobis[6-nitrobenzoic acid]. Reduction of the disulfide bonds in the vicinity of the receptor does not decrease the effect of cobrotoxin.Keywords
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