[1-[3-(Phenothiazin-10-yl)propyl]-4-piperidinyl]phenylmethanones, a novel class of long-acting neuroleptic agents

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Abstract
In previous studies the phenyl-4-piperidinylmethanone moiety was shown to be a neuroleptic pharmacophore. A short series of [1-[3-(phenothiazin-10-yl]-4-piperidinyl]phenylmethanones was prepared and tested for neuroleptic activity using the blockade of d-amphetamine lethality in aggregated mice and suppression of conditioned avoidance behavior as end points. Most compounds apparently were potent neuroleptic agents, and 2 possessed a long duration of action.

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