AORTIC COLLAGEN BIOSYNTHESIS DURING RENAL-HYPERTENSION, PREGNANCY AND HYPERTENSION DURING PREGNANCY IN RAT
- 1 January 1978
- journal article
- research article
- Vol. 28 (4) , 215-219
Abstract
Synthesis and deposition of collagen and other proteins was measured in the rat aorta by radiolabeling in short term organ culture. The synthesis of collagen and other proteins is linear for .gtoreq. 5 h. Autoradiography demonstrated labeling in all cell layers and protein deposition in the extracellular matrix. Hypertension was induced by renal ischemia using Goldblatt''s technique. Synthesis and deposition of collagen was stimulated in aorta from the 1st wk of hypertension and in pregnancy, and was more increased in hypertensive pregnant animals. Reserpine suppresses blood pressure rise in operated animals and prevents these modifications.This publication has 9 references indexed in Scilit:
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