Further Studies on the Mode of Action of Clostridium Welchii Type-D Epsilon Toxin
- 1 August 1978
- journal article
- research article
- Published by Microbiology Society in Journal of Medical Microbiology
- Vol. 11 (3) , 293-298
- https://doi.org/10.1099/00222615-11-3-293
Abstract
Intradermal injection of Clostridium welchii type-D epsilon toxin increased the permeability of blood vessels in guinea-pig skin to Evans blue dye by a mechanism not dependent on the release of histamine. The toxin was also found to raise the plasma concentration of cyclic adenosine 3′, 5′-monophosphate in mice. It is concluded that epsilon toxin is an enterotoxin capable of causing widespread damage, after binding to receptor sites on the surface of certain cells, through a mechanism mediated by an adenyl cyclase-cAMP system.This publication has 6 references indexed in Scilit:
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