Modulation of Cytokine Expression by Hypericum Extract
- 1 January 1994
- journal article
- research article
- Published by SAGE Publications in Journal of Geriatric Psychiatry and Neurology
- Vol. 7 (1_suppl) , 60-62
- https://doi.org/10.1177/089198879400701s16
Abstract
The effect of hypericum extract LI 160 on the stimulated cytokine expression was investigated in vitro in a whole blood culture system. Blood samples were taken from five healthy volunteers and four depressive patients. The release of interleukin-6 (IL-6), interleukin-lβ (IL-lβ) and tumor necrosis factor-α (TNF-α) was measured quantitatively after an incubation time of 24 hours on microtiter plates. A massive suppression of the interleukin-6 release was found for PHA-stimulated hypericum extract. Possible relations to the antidepressive effects of hypericum extract are discussed.Keywords
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