In Vitro Detection of Apoptosis in Monocytes/Macrophages Infected with Human Coronavirus
- 1 November 2002
- journal article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 9 (6) , 1392-5
- https://doi.org/10.1128/cdli.9.6.1392-1395.2002
Abstract
Human coronavirus (HCoV) strain 229E infection, but not HCoV strain OC43 infection, of monocytes/macrophages from healthy donors and patients with multiple sclerosis in remission resulted in increased apoptosis, as measured by DNA changes and annexin V staining. Apoptosis correlated with the differential release of infectious virus. HCoV strain 229E titers were 10(3.5) to 10(6) 50% tissue culture-infective doses (TCID(50))/ml, and HCoV strain OC43 titers were only 10(1.2) to 10(2.7) TCID(50)/ml.Keywords
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