The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy
Top Cited Papers
- 1 December 2005
- journal article
- review article
- Published by Wiley in British Journal of Pharmacology
- Vol. 146 (8) , 1041-1059
- https://doi.org/10.1038/sj.bjp.0706416
Abstract
The variety of factors and events involved in neurodegeneration renders the subject a major challenge. Neurodegenerative disorders include a number of different pathological conditions, which share similar critical metabolic processes, such as protein aggregation and oxidative stress, both of which are associated with the involvement of metal ions. In this review, Alzheimer's disease, Parkinson's disease and prion disease are discussed, with the aim of identifying common trends underlying these devastating neurological conditions. Chelation therapy could be a valuable therapeutic approach, since metals are considered to be a pharmacological target for the rationale design of new therapeutic agents directed towards the treatment of neurodegeneration.British Journal of Pharmacology (2005) 146, 1041–1059. doi:10.1038/sj.bjp.0706416Keywords
This publication has 169 references indexed in Scilit:
- Protein folding and misfoldingNature, 2003
- Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseasesNature, 2002
- Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformationProceedings of the National Academy of Sciences, 2000
- Protein misfolding and prion diseasesJournal of Molecular Biology, 1999
- The Role of Iron in NeurodegenerationDrugs & Aging, 1999
- AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's diseaseNature Genetics, 1998
- Mutation in the α-Synuclein Gene Identified in Families with Parkinson's DiseaseScience, 1997
- Deficiencies in Complex I subunits of the respiratory chain in Parkinson's diseaseBiochemical and Biophysical Research Communications, 1989
- Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brainJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1988
- Untersuchungen in der ChinolinreiheNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1932