In search of new methods in peptide synthesis. A review of the last three decades
- 1 May 1985
- journal article
- review article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 25 (5) , 449-474
- https://doi.org/10.1111/j.1399-3011.1985.tb02200.x
Abstract
An attempt was made to discern ideas and trends in the development of peptide synthesis and to recognize general principles of the discipline. Introduction of efficient methods of activation and coupling during the early years of the reviewed period was followed by only moderate further improvements. Major advances were achieved by the discovery of novel methods of protection and by techniques of facilitation. Improvements in the methods of deblocking hold considerable promise and might bring significantly closer the goal of peptide synthesis: the direct preparation of homogeneous products.Keywords
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