Biosynthesis of bitter acids in hops
Open Access
- 15 July 1999
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 263 (2) , 447-454
- https://doi.org/10.1046/j.1432-1327.1999.00518.x
Abstract
The biosynthesis of humulone, an antibacterial bitter acid from hops, was studied by isotope‐incorporation experiments using 13C‐labelled glucose or 2H2O. 13C enrichments, 2H enrichments and 13C13C coupling patterns identify isovaleryl‐CoA, malonyl‐CoA and dimethylallyl pyrophosphate as precursors for humulone. Dimethylallyl pyrophosphate, which serves as a building block for the bitter acid, is generated via the deoxyxylulose pathway of terpenoid biosynthesis. The data confirm that a symmetrical intermediate is involved in humulone formation.Keywords
This publication has 25 references indexed in Scilit:
- In-vitro prenylation of aromatic intermediates in the biosynthesis of bitter acids in humulus lupulusPhytochemistry, 1998
- The deoxyxylulose phosphate pathway of terpenoid biosynthesis in plants and microorganismsChemistry & Biology, 1998
- Terpenoid biosynthesis from 1-deoxy- d -xylulose in higher plants by intramolecular skeletal rearrangementProceedings of the National Academy of Sciences, 1997
- Formation of aromatic intermediates in the biosynthesis of bitter acids in Humulus lupulusPhytochemistry, 1995
- Einbau von 14C-mevalonsäurelacton in hopfenbitterstoffePhytochemistry, 1976
- Monoprenylierte acylphloroglucinePhytochemistry, 1976
- Aminosäuren als vorstufe der acylseitenkette der hopfenbitterstoffePhytochemistry, 1976
- Zur biogenese des sechsringes der hopfenbitterstoffePhytochemistry, 1976
- Einbau von [14C]-Essigsäure in hopfenbitterstoffePhytochemistry, 1974
- Bildung und weiterreaktion von acylvorstufen der hopfenbitterstoffePhytochemistry, 1974