Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist
- 1 June 1989
- journal article
- Published by Springer Nature in Nature
- Vol. 339 (6226) , 593-597
- https://doi.org/10.1038/339593a0
Abstract
The thyroid-hormone receptor can, in the absence of its ligand, suppress activity of a responsive promoter. Addition of thyroid hormone, however, results in the stimulation of expression. The oncogenic derivative of the thyroid-hormone receptor, v-erbA, acts as a constitutive repressor and, when coexpressed with the receptor, blocks activation by thyroid hormone. Thus, v-erbA may be the first example of a dominant negative oncogene.Keywords
This publication has 30 references indexed in Scilit:
- Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicingNature, 1989
- Steroid receptor-mediated inhibition of rat prolactin gene expression does not require the receptor DNA-binding domainCell, 1988
- v-erbA specifically suppresses transcription of the avian erythrocyte anion transporter (Band 3) geneCell, 1988
- The Approaching Era of the Tumor Suppressor GenesScience, 1987
- Identification of a receptor for the morphogen retinoic acidNature, 1987
- Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptorCell, 1987
- The Molecular Genetics of CancerScience, 1987
- A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcomaNature, 1986
- v-erbA cooperates with sarcoma oncogenes in leukemic cell transformationCell, 1986
- Transforming capacities of avian erythroblastosis virus mutants deleted in the erbA or erbB oncogenesCell, 1983