Baboon-to-Human Cardiac Xenotransplantation in a Neonate
- 20 December 1985
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 254 (23) , 3321-3329
- https://doi.org/10.1001/jama.1985.03360230053022
Abstract
This report details the first case of cardiac xenotransplantation in a neonate. The recipient, a victim of hypoplastic left heart syndrome (HLHS), survived 20 days. Autopsy findings are documented. The cardiac graft showed only traces of cell-mediated rejection. Graft failure appears to have resulted from a progressive, potentially avoidable humoral response, unmodified by immunosuppression. Cardiac allotransplantation and selective baboon-to-human xenotransplantation deserve further exploration as investigational therapy for neonatal HLHS. (JAMA1985;254:3321-3329)This publication has 1 reference indexed in Scilit:
- A History of Pediatric ImmunologyPediatric Research, 2005