Tissue Specificity of the Epididymal Androgen Dependent Phospholipase A

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Abstract
The effect of androgens on phospholipase A in the rat epididymis, liver, heart, kidney, prostate and epididymal fat pad was investigated in the cytosol and in a postmitochondrial particulate cell fraction. In both cell fractions, phospholipase A activity was 10-15 times higher in the cauda epididymidis than in the other organs, including the caput epididymidis; the corpus showed an intermediate activity. In the cauda and corpus, castration reduced phospholipase A activity in subcellular fractions to the same level as found in the other organs, and testosterone supplementation restored the enzyme activity. No evidence of a similar androgen controlled phospholipase A was found in any other tissue examined, including the prostate.

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