Alkynylation of halopyridazines and their N-oxides.

1 January 1980

journal article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 28 (12) , 3488-3493
https://doi.org/10.1248/cpb.28.3488

Abstract

Various 3-alkynylpyridazines have been prepared by cross-coupling of 3-halopyridazines and monosubstituted acetylenes in Et₂NH with Pd (PPh₃)₂Cl₂-CuI as a catalyst. Though the alkynylation of 3-chloropyridazine 1-oxides afforded 3-alkynylpyridazine 1-oxides, attempts to obtain 3-chloropyridazine 2-oxides were unsuccessful. N-Oxidation of 3-alkynylpyridazines with m-chloroperbenzoic acid yielded their 1-oxides exclusively

Keywords

ACETYLENES
CUI
ATTEMPTS
MONOSUBSTITUTED
CHLOROPERBENZOIC
2CL2
ALKYNYLPYRIDAZINES
HALOPYRIDAZINES
ET2NH

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