The Dual-System Hypothesis of Pain Perception
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Neurological Research
- Vol. 3 (1) , 317-327
- https://doi.org/10.1080/01616412.1981.11739607
Abstract
We describe a dual-system hypothesis relating the seemingly contradictory findings reported in clinical and experimental investigations of pain. This incorporates a model in which two neuronal systems are related, involving Substance P (SP) and Enkephalin (E). This model uses feedback loops holding the systems in balance. The analogy to a control system is also made.Keywords
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