Skin lesions in angioimmunoblastic lymphadenopathy: histological and immunological studies

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Abstract
Angioimmunoblastic lymphadenopathy with dysproteinemia is reported (AILD) in 4 patients with different skin pictures. As the disease progresses 2 main forms predominate, papulonodular and erythroderma. In all cases the histological picture of the skin mirrors that of the lymph node. Results point to an increase in the peripheral blood, lymph nodes and skin of T and subsequently of B lymphocytes, suggesting that a proliferation of helper T cells and activation of the B cell subpopulation may be involved in the pathogenesis of some cases of AILD.