Solid-Phase Synthesis of a Fragment of the Capsular Polysaccharide ofHaemophilus InfluenzaeType B UsingH-Phosphonate Intermediates
- 1 April 1992
- journal article
- research article
- Published by Taylor & Francis in Journal of Carbohydrate Chemistry
- Vol. 11 (3) , 265-285
- https://doi.org/10.1080/07328309208017993
Abstract
A pentameric fragment of the capsular polysaccharide of Haemophilus influenzae type b, containing a linker group, was synthesized by a simple solid-phase procedure. Cross-linked polystyrene was used as a solid phase, and a benzyl-protected ribosylribitol H-phosphonate was used as monomer. A non-promoted glycosidation reaction was used for preparation of the ribosylribitol monomer.Keywords
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